Viagra may be useful against Alzheimer's dementia
Viagra, also known as sildenafil, was originally designed as a heart drug because of its main action - improving blood flow by relaxing or widening blood vessels.
Look after your heart
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Take the blue pill
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Re: Take the blue pill
redsturgeon wrote:But how will I cope with the side effects?
John
Never mind those, what about the front effects?
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Re: Take the blue pill
I've gone for the new one, I think it's called mycoxaflopin.
https://unijokes.com/viagra-jokes/
Wrong board!
https://unijokes.com/viagra-jokes/
Wrong board!
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Re: Take the blue pill
redsturgeon wrote:But how will I cope with the side effects?
John
A good multivitamin
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Re: Take the blue pill
Probably makes sense for vascular dementia / alzheimers.
One of the 3 doctors that invented Viagra (Sildenafil) wrote a book "No More Heart Disease". The premise is that they were looking for a way to treat high blood pressure and other vascular issues, and stumbled on Viagra because of it's PDE5 inhibition properties.
My non-medical doctor understanding is:
More Nitric Oxide (NO) in the veins and arteries ---> better endothelial (inner lining of the arteries / veins) health ---> better NO response ---> less risk and chance of inflammation in the arteries (inflammation causes rupture in endothelial cells, which causes cholesterol and calcium to be sent there to plug up the damage (think of this like a scab forming to heal your hand after you get cut) --> Lower blood pressure and better vascular function.
cGMP is involved with this process, but gets destroyed by PDE5. So Viagra inhibits PDE5, helps cGMP keep active for longer, and keeps the NO and blood vessels opened up for longer. Hence... the infamous effects of Viagra
So it does seem to make sense that taking Viagra (with doctor's supervision) may help keep the blood vessels open and protect the inner linings of the arteries and keep nutrients flowing to the brain and other parts of the body. (Hence some people take semi-essential amino acids like l-arginine and l-citrulline, which are also vasodilators.)
One of the 3 doctors that invented Viagra (Sildenafil) wrote a book "No More Heart Disease". The premise is that they were looking for a way to treat high blood pressure and other vascular issues, and stumbled on Viagra because of it's PDE5 inhibition properties.
My non-medical doctor understanding is:
More Nitric Oxide (NO) in the veins and arteries ---> better endothelial (inner lining of the arteries / veins) health ---> better NO response ---> less risk and chance of inflammation in the arteries (inflammation causes rupture in endothelial cells, which causes cholesterol and calcium to be sent there to plug up the damage (think of this like a scab forming to heal your hand after you get cut) --> Lower blood pressure and better vascular function.
cGMP is involved with this process, but gets destroyed by PDE5. So Viagra inhibits PDE5, helps cGMP keep active for longer, and keeps the NO and blood vessels opened up for longer. Hence... the infamous effects of Viagra
So it does seem to make sense that taking Viagra (with doctor's supervision) may help keep the blood vessels open and protect the inner linings of the arteries and keep nutrients flowing to the brain and other parts of the body. (Hence some people take semi-essential amino acids like l-arginine and l-citrulline, which are also vasodilators.)
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Re: Take the blue pill
AsleepInYorkshire wrote:Viagra may be useful against Alzheimer's dementia
Viagra, also known as sildenafil, was originally designed as a heart drug because of its main action - improving blood flow by relaxing or widening blood vessels.
Look after your heart
Firstly, understand I never was a watcher of Top Gear (not really my thing), however I have seen a few episodes.
Do you remember that old episode of Top Gear when they took some vehicles to somewhere in South America? They were going to drive the vehicles over a high mountain range and down the other side to the coast. Before they really started the main journey up over the mountains Jeremy Clarkson stopped, called them together and gave them all a Viagara pill - you can imagine the remarks.
He explained to the 'boys' and us, the potential hazard of strokes.
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