If you run a local tmux and remote tmux then you pretty much have to redefine the control keys so that they don't conflict. On hashbang I've set it to be the backtick (below the escape key) - which means that if I want to actually type a backtick I have to press it twice in quick succession. Not used that much as a character other than as execute quotes in shell scripts.
mc is great .. you can even create different user menus in different folders. My main one (when I press F2) looks like ...
So F1 to drop down tilda (that terminal screen), F2 in mc to show the menu and I've set P to poweroff, R to reboot ...etc. Three quick succession keystrokes to initiate (highly configurable) actions.
Good to set separate mc themes on different boxes. Otherwise for instance if I'm running mc on hashbang as well as locally in different tmux panes then you can lose track of where you are.
With tmux some like to zoom/unzoom panes, a form of windows where you can see many on a single screen and flip between them and then full screen zoom/unzoom the window/pane, personally I prefer to just flip between full windows rather than using panes. So in my case backtick 1, 2, 3 or whatever window I want to switch to. For instance whilst viewing irc backtick 2 would switch to email
Hashbang has been continually up for 35 days as per that image, its usually over 100 days before they do reboot - which can be a little annoying as all of the things you'd left running such as irc then have to be restarted/logged into again. But otherwise you can (in my backtick as the control key setup) backtick d to disconnect, and then later reattach again from the same or different devices, even your mobile and carry on from where you'd left.
I have tilda set to open up down to the taskbar, so that's still visible. Or F1 to hide tilda and reveal the usual desktop/icons. So all text and gui on the same single desktop, rather than using ctrl-alt-F2 ... or whatever to flip between different desktop sessions.
htop for process/processor monitoring is another nice cli tool
That 128 processor getting on for 1TB of ram ... isn't my laptop before you ask. Probably will have to wait until 2030 or so before that is the case