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AstraZeneca PLC (AZN)

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dealtn
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Re: AstraZeneca PLC (AZN)

#459697

Postby dealtn » November 20th, 2021, 7:55 pm

Bouleversee wrote:
dealtn wrote:
Bouleversee wrote:Wouldn't you have expected that news to make the s.p. rocket but it's back to less than I topped up at months ago? I shall never understand the stock market. It's just what those of us who are old and/or vulnerable need as we haven't a clue what our antibody levels are and how safe it is to resume a reasonably normal life.


Not necessarily. What's the route for this to be an increased monetised benefit to the company?

AZN have been operating a (quasi) not-for-profit Covid vaccine product anyway. Is this going to change?

Even if so, there are 2 effects here. One, this new drug is more compelling relative to it's competitors (than previously thought). So potentially more demand (and often increased margin too). Secondly the life of the product is extended, which actually reduces demand for it, and previous alternatives. (Think about light bulbs - if the "forever" bulb was invented, you would only buy it once).

What is the compelling reason for a rocketing share price in your view? You hint that for people like you, perhaps, old and vulnerable and rather nervous, this is a good thing. It quite probably is. But how much are you willing to pay for it? I suspect most will expect it to be free (to them at the point of delivery) on the NHS.


AZN is already charging for their vaccine, apart from the poorer countries. If you missed that, you may also have missed research reports which had shown that some people, Asians in particular, were genetically more pre-disposed to suffer severe consequences from Covid infection and that immuno-compromised people did not produce any antibodies. Since our antibody levels are not routinely tested after vaccination, we don't know to what extent we are protected even though some of us have had 3 jabs this year. Assuming the outcome of the trials is positive and approval is forthcoming, and assuming the cost of one dose of the new drug is no more than 2 or 3 doses of any vaccine and bearing in mind the saving on administering it, freeing up medical staff for other essential but now delayed purposes, plus the possibility that many more lives could be saved I should have thought AZN would be on a win-win and yes, I would expect to get it on the NHS if appropriate for me. Why not? I don't have to pay for my jabs. However, I am just a dippy old Doris who doesn't claim to be an expert, unlike you. I thought there would be an immediate rise in the s.p. even if it fell back again if further news was disappointing. It remains to be seen how this will develop.

I haven't heard anything about the price as yet. Have you heard that the cost would be astronomic compared with the cost of the vaccines?


I'm not claiming to be an expert - show me where you think I have.

You asked a question "wouldn't you have expected that news to make the sp rocket?"

I answered the question. If you don't like my answer, or now prefer to ask an alternative, well fine. I think my response is a reasonable one. The share price will only rise, let alone rocket, if this is something that monetises the future cashflows more positively than the market was previously expecting. I don't think it does. The market agreed.

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Re: AstraZeneca PLC (AZN)

#461972

Postby idpickering » November 30th, 2021, 7:08 am

Lynparza granted FDA Priority Review for OlympiA

AstraZeneca's supplemental New Drug Application (sNDA) for Lynparza (olaparib) has been accepted and granted Priority Review in the US for the adjuvant treatment of patients with BRCA-mutated (BRCAm) HER2-negative high-risk early breast cancer who have already been treated with chemotherapy either before or after surgery.


https://www.investegate.co.uk/astrazene ... 00060051U/

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Re: AstraZeneca PLC (AZN)

#463700

Postby idpickering » December 7th, 2021, 7:13 am

AstraZeneca, Ionis to collaborate on eplontersen

AstraZeneca has entered into a new global development and commercialisation agreement with Ionis Pharmaceuticals, Inc. (Ionis) for eplontersen, formerly known as IONIS-TTR-LRX. Eplontersen is a ligand-conjugated antisense investigational medicine currently in Phase III clinical trials for amyloid t ransthyretin cardiomyopathy (ATTR-CM) and amyloid t ransthyretin polyneuropathy (ATTR-PN). It is designed to reduce the production of transthyretin (TTR protein) to treat both hereditary and non-hereditary forms of TTR amyloidosis (ATTR).


https://www.investegate.co.uk/astrazene ... 00048023U/

Ian.

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Re: AstraZeneca PLC (AZN)

#467575

Postby idpickering » December 20th, 2021, 3:59 pm

Tezspire approved in the US for severe asthma

AstraZeneca and Amgen's Tezspire (tezepelumab-ekko) has been approved in the US for the add-on maintenance treatment of adult and paediatric patients aged 12 years and older with severe asthma.


https://www.investegate.co.uk/astrazene ... 05061205W/

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Re: AstraZeneca PLC (AZN)

#467713

Postby idpickering » December 21st, 2021, 7:14 am

Ultomiris accepted for FDA Priority Review for gMG

Ultomiris regulatory submission accepted under FDA Priority Review in the US for adults with generalised myasthenia gravis

Submission based on positive Phase III trial in which Ultomiris significantly improved functional activities as measured by Myasthenia Gravis-Activities of Daily Living Profile

The supplemental Biologics License Application (sBLA) for Ultomiris (ravulizumab-cwvz) in adults with generalised myasthenia gravis (gMG) has been accepted for Priority Review by the US Food and Drug Administration (FDA).


https://www.investegate.co.uk/astrazene ... 00053208W/

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Re: AstraZeneca PLC (AZN)

#468159

Postby idpickering » December 23rd, 2021, 7:19 am

AZN's Vaxzevria significantly boosted antibody levels against Omicron

University of Oxford study supports use of Vaxzevria as third dose booster against Omicron

Neutralising antibody levels against Omicron following a third dose boost of Vaxzevria were broadly similar to levels achieved after two doses against the Delta variant

AstraZeneca’s Vaxzevria (ChAdOx1-S [Recombinant]) significantly boosted levels of antibodies against the Omicron SARS-CoV-2 variant (B.1.1.529) following a third dose booster, according to data from a new laboratory study.1

Neutralisation titres for Omicron were boosted following a third dose with Vaxzevria compared to titres after a second dose.1 The levels seen after the third dose booster were higher than the neutralising antibodies found in individuals who had been previously infected with and recovered naturally from COVID-19 (Alpha, Beta, Delta variants and original strain).1 Sera obtained from individuals one month after receiving the third dose booster vaccination neutralised the Omicron variant to levels that were broadly similar to those observed one month after the second dose against the Delta variant.1 Two doses of Vaxzevria have been associated with protection against the Delta variant in real world studies.2,3

The study analysed blood samples taken from individuals infected with COVID-19; those who had been vaccinated with a two-dose schedule and a third dose booster; and those who had reported previous infection from other COVID-19 variants of concern. The study included samples from 41 individuals who had received three doses of Vaxzevria.1

The study was performed independently by investigators at the University of Oxford and the findings were posted online on the bioRxiv pre print server.

Professor Sir John Bell, Regius Professor of Medicine, University of Oxford, UK and one of the study investigators, said: “It is very encouraging to see that current vaccines have the potential to protect against Omicron following a third dose booster. These results support the use of third dose boosters as part of national vaccine strategies, especially to limit the spread of variants of concern, including Omicron.”


https://news.cision.com/se/astrazeneca/ ... straZeneca’s%20Vaxzevria%20(ChAdOx1-S%20[Recombinant])%20significantly%20boosted%20levels%20of,according%20to%20data%20from%20a%20new%20laboratory%20study.1

idpickering
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Re: AstraZeneca PLC (AZN)

#468930

Postby idpickering » December 29th, 2021, 8:35 am

AstraZeneca and Ionis close eplontersen deal

AstraZeneca has closed a global development and commercialisation agreement with Ionis Pharmaceuticals, Inc. (Ionis) for eplontersen, formerly known as IONIS-TTR-LRX.

The companies will jointly develop and commercialise eplontersen in the US, while AstraZeneca will develop and commercialise it in the rest of the world, except in Latin America.

Financial considerations

Under the terms of the agreement, the upfront payment from AstraZeneca to Ionis is $200m. AstraZeneca will make additional conditional payments of up to $485m following regulatory approvals. It will also pay up to $2.9bn of sales-related milestones based on sales thresholds between $500m and $6bn, plus royalties in the range of low double-digit to mid-twenties percentage depending on the region. The collaboration includes territory-specific development, commercial and medical affairs cost-sharing provisions.

The transaction will be funded with cash and is expected to be neutral to Core earnings in 2021. It will be accounted for as an intangible asset acquisition, recognised initially at the upfront amount, with any potential future milestone payments capitalised into the intangible asset as they are recognised.

Ionis will continue to manufacture and supply eplontersen for the existing clinical studies and process qualification. AstraZeneca will be responsible for commercial supply, with transition timing to be agreed by both parties. AstraZeneca will book all sales generated under the agreement.


https://www.investegate.co.uk/astrazene ... 00118221W/

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Re: AstraZeneca PLC (AZN)

#471141

Postby idpickering » January 7th, 2022, 2:30 pm

AstraZeneca and Neurimmune sign deal for NI006

Alexion, AstraZeneca's Rare Disease group, has entered into an exclusive global collaboration and licence agreement with Neurimmune AG for NI006, an investigational human monoclonal antibody currently in Phase Ib development for the treatment of transthyretin amyloid cardiomyopathy (ATTR-CM). NI006 specifically targets misfolded transthyretin and is designed to directly address the pathology of ATTR-CM by enabling removal of amyloid fibril deposits in the heart, with the potential to treat patients with advanced ATTR-CM.

Under the agreement, Alexion will be granted an exclusive worldwide licence to develop, manufacture and commercialise NI006.


https://www.investegate.co.uk/astrazene ... 00077555X/

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Re: AstraZeneca PLC (AZN)

#473665

Postby idpickering » January 17th, 2022, 7:07 am

Enhertu granted Priority Review for breast cancer

AstraZeneca and Daiichi Sankyo have received notification of acceptance of the supplemental Biologics License Application (sBLA) of Enhertu (trastuzumab deruxtecan) for the treatment of adult patients in the US with unresectable or metastatic HER2-positive breast cancer who have received a prior anti-HER2-based regimen. The application has also been granted Priority Review.


https://www.investegate.co.uk/astrazene ... 00075614Y/

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Re: AstraZeneca PLC (AZN)

#474283

Postby idpickering » January 19th, 2022, 7:36 am

Two releases today.

Imfinzi improves survival in biliary tract cancer

https://www.investegate.co.uk/astrazene ... 05088834Y/

Imfinzi combo shows unprecedented survival in HCC

https://www.investegate.co.uk/astrazene ... 00078833Y/

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Re: AstraZeneca PLC (AZN)

#479637

Postby idpickering » February 10th, 2022, 7:12 am

Full year and Q4 2021 results

· Total Revenue increased 41% (38% at CER1) to $37,417m including COVID-19 vaccine revenues. Total Revenue excluding vaccine increased 26% (23% at CER) to $33,436m. In Q4 2021, Total Revenue increased 62% (63% CER) to $12,011m

· Reported2 EPS3 of $0.08 (FY 2020: $2.44) and Core4 EPS of $5.29 (FY 2020: $4.02)

· 14 positive Phase III readouts across nine medicines in 2021, and 22 regulatory approvals and authorisations in major markets including five NMEs5

· FY 2022 guidance at CER of a high-teens percentage increase in Total Revenue and a mid-to-high twenties percentage increase in Core EPS

· Reflecting increased confidence in future growth and cash generation, the Board intends to increase the annualised dividend by $0.10 to $2.90, and has approved a second interim dividend for FY 2021 of $1.97, payable in March 2022. This results in a total dividend declared for FY 2021 of $2.87

Pascal Soriot, Chief Executive Officer, AstraZeneca, said: "AstraZeneca continued on its strong growth trajectory in 2021, with industry-leading R&D productivity, five of our medicines crossing new blockbuster thresholds, and the acquisition and integration of Alexion. We also delivered on our promise of broad and equitable access to our COVID-19 vaccine with 2.5 billion doses released for supply around the world, and we made good progress on reducing our greenhouse gas emissions.

Growth was well balanced across our strategic areas of focus, and we saw double-digit growth in all major regions, including Emerging Markets despite some headwinds in China.

The positive news from our pipeline, including approvals for Evusheld and Tezspire, supports the outlook for 2022. This, along with the transformative acquisition of Alexion, means that we are confident in our long term growth and profitability. After a landmark year in 2021, we are increasing the dividend for our shareholders."

The record date for the second interim dividend for 2021, payable on 28 March 2022, will be 25 February 2022. The ex-dividend date will be 24 February 2022.



https://www.investegate.co.uk/astrazene ... 00032236B/

idpickering
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Re: AstraZeneca PLC (AZN)

#479655

Postby idpickering » February 10th, 2022, 8:34 am

The results above have gone down well it seems, with AZN being up 3.6% as I type. I'm a long term happy holder of the share, but am unlikely to top up my holdings any time soon.

Ian.

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Re: AstraZeneca PLC (AZN)

#479681

Postby yorkshirelad1 » February 10th, 2022, 9:38 am

And slight increase in the $ div from $2.80 to $2.90 (which translates into pence as 207 to 210.1p)
(it's been at $2.80 since 2013)

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Re: AstraZeneca PLC (AZN)

#479713

Postby tjh290633 » February 10th, 2022, 10:53 am

From Note (g)

g) Dividend per share

The Board reaffirms its commitment to the progressive dividend policy. A second interim dividend of $1.97 per share (145.3 pence, 18.00 SEK) has been declared, meaning a full-year dividend per share of $2.87 (210.1 pence, 25.77 SEK). Dividend payments are normally paid as follows:

- First interim dividend - announced with half-year and second-quarter results and paid in September

- Second interim dividend - announced with full-year and fourth-quarter results and paid in March

The record date for the second interim dividend for 2021, payable on 28 March 2022, will be 25 February 2022. The ex-dividend date will be 24 February 2022. The record date for the first interim dividend for 2022, payable on 12 September 2022, will be 12 August 2022. The ex-dividend date will be 11 August 2022


TJH

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Re: AstraZeneca PLC (AZN)

#479730

Postby Dod101 » February 10th, 2022, 11:20 am

yorkshirelad1 wrote:And slight increase in the $ div from $2.80 to $2.90 (which translates into pence as 207 to 210.1p)
(it's been at $2.80 since 2013)


Good. I thought that but did not have time to check it. Maybe they have at last turned the corner.

Dod

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Re: AstraZeneca PLC (AZN)

#479733

Postby Dod101 » February 10th, 2022, 11:23 am

idpickering wrote:The results above have gone down well it seems, with AZN being up 3.6% as I type. I'm a long term happy holder of the share, but am unlikely to top up my holdings any time soon.

Ian.


Sadly the market movement probably means nothing because it has been like a yo-yo for the last couple of years, near enough.

Dod

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Re: AstraZeneca PLC (AZN)

#479772

Postby idpickering » February 10th, 2022, 1:15 pm

Dod101 wrote:
idpickering wrote:The results above have gone down well it seems, with AZN being up 3.6% as I type. I'm a long term happy holder of the share, but am unlikely to top up my holdings any time soon.

Ian.


Sadly the market movement probably means nothing because it has been like a yo-yo for the last couple of years, near enough.

Dod



You're probably right Dod. Either way, I'm happy to continue holding the share for the long term.

Ian.

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Re: AstraZeneca PLC (AZN)

#479773

Postby Dod101 » February 10th, 2022, 1:19 pm

idpickering wrote:
Dod101 wrote:
idpickering wrote:The results above have gone down well it seems, with AZN being up 3.6% as I type. I'm a long term happy holder of the share, but am unlikely to top up my holdings any time soon.

Ian.


Sadly the market movement probably means nothing because it has been like a yo-yo for the last couple of years, near enough.

Dod



You're probably right Dod. Either way, I'm happy to continue holding the share for the long term.

Ian.


Yes I did not intend to be mean about your comment but I think/hope that the modest increase in the dividend is a decent pointer but the share price has been very volatile over the last two or three years. I will simply continue to hold.

Dod

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Re: AstraZeneca PLC (AZN)

#479776

Postby idpickering » February 10th, 2022, 1:24 pm

Dod101 wrote:
Yes I did not intend to be mean about your comment but I think/hope that the modest increase in the dividend is a decent pointer but the share price has been very volatile over the last two or three years. I will simply continue to hold.

Dod


Thanks Dod, although tbh, that's not how I read your comment anyway. No worries.

Ian.

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Re: AstraZeneca PLC (AZN)

#479982

Postby ADrunkenMarcus » February 11th, 2022, 10:19 am

The increase in the annual dividend from $2.80 to $2.87 - or 2.5 percent - is welcome.

Although Astra has taken on significant debt in recent years, consensus forecasts are for a very strong increase in free cash flow by 2023. If they achieve that then they will hopefully have scope to deliver further dividend growth as well as deleveraging, because debt is forecast to fall substantially too - both in absolute terms and relative to free cash flow. On the basis of forecasts for 2023, Astra is trading on a forward 5.8 percent free cash flow yield.

Astra delivered very strong dividend growth in the 2000s, then froze the dividend at a high level in the 2010s, so I hope the 2020s will revert to the earlier pattern. The strong dividend growth of the 2000s gives me a decent CAGR in dividend per share since 1998, despite the decade long freeze. I remember in 2014 that the 2023 revenue target was widely questioned and yet they have got there.

Best wishes


Mark.


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