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AstraZeneca PLC (AZN)

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Dod101
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Re: AstraZeneca PLC (AZN)

#567334

Postby Dod101 » February 9th, 2023, 11:47 pm

idpickering wrote:
Bubblesofearth wrote:Shares up 2.5% as I write and have been my best performer since purchase over 10 years ago.

I'm a very happy shareholder :D

BoE


Agreed, and likewise. There is a temptation to trim my holdings tbh as they've become very overweight in my HYP. HYP chat is not for hereabouts though. ;)

Ian.


No but discussing trimming is surely acceptable. This is not the HYP Board! I trimmed on 3 January at £114.

Dod

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Re: AstraZeneca PLC (AZN)

#567337

Postby Dod101 » February 9th, 2023, 11:52 pm

yorkshirelad1 wrote:
Dod101 wrote:[snip] but the dividend is still being held. Dod


The results (https://www.astrazeneca.com/media-centre/press-releases/2023/full-year-and-q4-2022-results.html) show a full year dividend held at $2.90. The results also note a full year dividend of 239.2 pence. That's compared to 210.1p last year. I make that +13.9% . Just saying.


But that is I think entirely down to exchange rates. do not forget that the report in US Dollars. It is fortunate that we are being paid in Sterling.

I think we need to view Astrazeneca as a machine which produces decent capital profits from its share price but not dividends. Every share is different.

Dod

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Re: AstraZeneca PLC (AZN)

#567354

Postby idpickering » February 10th, 2023, 2:48 am

Dod101 wrote:
idpickering wrote:
Agreed, and likewise. There is a temptation to trim my holdings tbh as they've become very overweight in my HYP. HYP chat is not for hereabouts though. ;)

Ian.


No but discussing trimming is surely acceptable. This is not the HYP Board! I trimmed on 3 January at £114.

Dod


Agreed, and I know this isn’t the HYP board. I only mentioned that to save a mod the time for rebuking me.

Ian.

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Re: AstraZeneca PLC (AZN)

#567441

Postby Bubblesofearth » February 10th, 2023, 2:24 pm

scrumpyjack wrote:
Core eps excludes things like legal costs, aborted development costs, write offs etc all of which happen every year and are a normal part of being a pharmaceutical company and are cash costs in the long term. But all pharma companies focus on an adjusted or core figure which excludes them.
If you look at their balance sheet over the years the cash goes down and the borrowings go up. The SP is forward looking and the hope is that at some point the actual cash profits will be similar to the core profit, but that tomorrow never seems to come. I don't have any pharma shares (did have some AZN but sold some and gave the rest to the grandchildren) because, as a retired chartered accountant I have this old fashioned preference for companies that make actual cash profits which more than cover their dividends and do not have large special write offs every year.


There are plus and minus points for all companies but at any given time these are well known to the market. If you can find some with good divi cover, excellent growth prospects, no regulatory issues, no large annual write-offs and sitting on an attractive P/E and yield then congratulations and please share!

The fact remains that AZN have been an incredible profitable share to own for the last however many years.

BoE

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Re: AstraZeneca PLC (AZN)

#567445

Postby scrumpyjack » February 10th, 2023, 2:52 pm

Bubblesofearth wrote:
scrumpyjack wrote:
Core eps excludes things like legal costs, aborted development costs, write offs etc all of which happen every year and are a normal part of being a pharmaceutical company and are cash costs in the long term. But all pharma companies focus on an adjusted or core figure which excludes them.
If you look at their balance sheet over the years the cash goes down and the borrowings go up. The SP is forward looking and the hope is that at some point the actual cash profits will be similar to the core profit, but that tomorrow never seems to come. I don't have any pharma shares (did have some AZN but sold some and gave the rest to the grandchildren) because, as a retired chartered accountant I have this old fashioned preference for companies that make actual cash profits which more than cover their dividends and do not have large special write offs every year.


There are plus and minus points for all companies but at any given time these are well known to the market. If you can find some with good divi cover, excellent growth prospects, no regulatory issues, no large annual write-offs and sitting on an attractive P/E and yield then congratulations and please share!

The fact remains that AZN have been an incredible profitable share to own for the last however many years.

BoE


There were many years when they were a very bad investment, with patents expiring and seemingly very little in the pipeline. Eventually Pfizer bid for them. Pharma have the big problem that they have to work very hard to discover and develop new drugs. If they succeed, they make hay for a few years, but then the patents expire and they have to start all over again! I had a reasonably large holding which I sold in 2013 as they had been such a poor performer for so long. For the moment things look good for them because their development pipeline looks very promising. They may well continue to be an excellent investment but history shows they are cyclical and have to keep reinventing new wheels.
I would have done better continuing to hold them, but did very well in builders and miners (who do make real profits and cash without exceptional items every year or having to fiddle their presentation of results). They too are cyclical, obviously.

All this illustrates is why one should have diversification in one’s portfolio.

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Re: AstraZeneca PLC (AZN)

#567472

Postby Bubblesofearth » February 10th, 2023, 4:43 pm

scrumpyjack wrote:
There were many years when they were a very bad investment, with patents expiring and seemingly very little in the pipeline. Eventually Pfizer bid for them. Pharma have the big problem that they have to work very hard to discover and develop new drugs. If they succeed, they make hay for a few years, but then the patents expire and they have to start all over again! I had a reasonably large holding which I sold in 2013 as they had been such a poor performer for so long. For the moment things look good for them because their development pipeline looks very promising. They may well continue to be an excellent investment but history shows they are cyclical and have to keep reinventing new wheels.
I would have done better continuing to hold them, but did very well in builders and miners (who do make real profits and cash without exceptional items every year or having to fiddle their presentation of results). They too are cyclical, obviously.

All this illustrates is why one should have diversification in one’s portfolio.


Sounds like you hit a period of AZN shares going nowhere. Certainly in the naughties they did little. However, over the longest time horizon, i.e. since splitting off from ICI, they have risen almost 20X. And paid a dividend all that time as well.

Miners have had a good time of it recently on the back of commodity prices but, as you say, very cyclical and can assume frightening levels of debt. I had a small punt in Scotgold a while ago and had to swallow a near 30% drop in the SP this morning as they annunced the need to raise more funds. Money down a hole in the ground as they sometimes say of the sector.

Absolutely no argument re diversification, the one free lunch the market offers.

BoE

Dod101
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Re: AstraZeneca PLC (AZN)

#567475

Postby Dod101 » February 10th, 2023, 4:57 pm

I have held Astrazeneca for a long time and prior to about mid 2017, they went nowhere for years at around £40/45. They have had a good run since then from about £50 to the current £100 plus. I would not call that spectacular and were it not for the poor showing of the whole UK market for a many years it would not look so good. The dividend has also been held for years on end. However, I am now happy to see the price doing quite well. I hope it holds its gains but took some profits at the beginning of last month to secure some gains.

Dod

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Re: AstraZeneca PLC (AZN)

#567497

Postby Bouleversee » February 10th, 2023, 6:35 pm

I'm surprised there hasn't been any discussion on here (unless I missed it) about Soriot's decision to open a $360m manufacturing plant in Ireland rather than here because "the tax rate (here) was discouraging". There is a large comment about this in Alistair Osbourne's Business Commentary in The Times Business today. If you Google the heading "Astra boss deserves to be listened to" non-subscribers may be able to get it. Apparently Soriot has been complaining about company taxation here for some time as well as the withdrawal of investment relief and the ballooning costs of VPAS. I'm not clear as to how locating the plant in Ireland is going to help this unless he creates a new company there but I don't claim to understand corporate taxation.

I hadn't realised Soriot was earning £14m. In his shoes I would feel very uncomfortable about taking so much when payments to shareholders were being restricted.

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Re: AstraZeneca PLC (AZN)

#567532

Postby Bubblesofearth » February 10th, 2023, 8:31 pm

Bouleversee wrote:
I hadn't realised Soriot was earning £14m. In his shoes I would feel very uncomfortable about taking so much when payments to shareholders were being restricted.


Are you talking about dividend payments? This seems to be a peculiar obsession hereabouts and not one that is widely observed outside the UK. Surely it's more important that companies with growth potential reinvest as well as pay out? The growth potential for healthcare is massive given ageing populations in many developed countries and the still large number of unmet needs.

Personally, as a shareholder, I would not want AZN to be paying higher divis just now.

BoE

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Re: AstraZeneca PLC (AZN)

#567540

Postby Bouleversee » February 10th, 2023, 9:50 pm

Bubblesofearth wrote:
Bouleversee wrote:
I hadn't realised Soriot was earning £14m. In his shoes I would feel very uncomfortable about taking so much when payments to shareholders were being restricted.


Are you talking about dividend payments? This seems to be a peculiar obsession hereabouts and not one that is widely observed outside the UK. Surely it's more important that companies with growth potential reinvest as well as pay out? The growth potential for healthcare is massive given ageing populations in many developed countries and the still large number of unmet needs.

Personally, as a shareholder, I would not want AZN to be paying higher divis just now.

BoE


Nor would I on the basis of their latest figures, as interpreted on here. However, pension funds and pensioners do generally need a reasonable income from their investments and if belts have to be tightened for the sake of future growth, I don't think it''s a good look for the ceo to be taking quite so much.. It has been known for ceos to decline some of their entitlement in similar circumstances. We have enjoyed good growth over a long period but if inflation causes potential investors to look elsewhere for higher income or indeed current holders to sell, our gains may diminish, especially if the govt. cannot be persuaded or cannot afford to give pharma a better deal. This has happened with several of my best holdings. I have learned the bitter lesson that a profit is not a profit until realised.

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Re: AstraZeneca PLC (AZN)

#567563

Postby Bubblesofearth » February 11th, 2023, 8:20 am

Bouleversee wrote:However, pension funds and pensioners do generally need a reasonable income from their investments


Do you have a link showing the importance of dividends in the provision of this income? I've had a search and can't get past how pension funds invest, i.e. diversity of assets managed.

I'm not saying you are wrong, and I've heard people talk about the importance of dividends, but I just can't seem to find anything definitive. ISTM that, just as for individual investors, fund income from equities could theoretically come from either or both of capital growth and dividends. It would be interesting to know how this is managed, especially in countries (e.g. US) where dividend yield is so much lower.

BoE

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Re: AstraZeneca PLC (AZN)

#568125

Postby ADrunkenMarcus » February 13th, 2023, 8:46 pm

Bouleversee wrote:I hadn't realised Soriot was earning £14m. In his shoes I would feel very uncomfortable about taking so much when payments to shareholders were being restricted.


OTOH, he has delivered.

Consensus forecasts (SharePad) show free cash flow rising 25% in 2023, 29% in 2024 and 10% in 2025. Astra trades on a 4.1% free cash flow yield today. If we assume the same valuation at end 2025, the share price would rise a further 76%. Total return would be higher with three years' of dividends (also forecast to rise) and debt to free cash flow will be comfortably below 1 in 2025 (FWIW - all forecasts are best guesses!)

Best wishes


Mark.

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Re: AstraZeneca PLC (AZN)

#568133

Postby csearle » February 13th, 2023, 9:41 pm

ADrunkenMarcus wrote:OTOH, he has delivered.
When a team reaches the quarter finals, how much is that down to the manager and how much to the team? C.

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Re: AstraZeneca PLC (AZN)

#568134

Postby ADrunkenMarcus » February 13th, 2023, 9:43 pm

csearle wrote:
ADrunkenMarcus wrote:OTOH, he has delivered.
When a team reaches the quarter finals, how much is that down to the manager and how much to the team? C.


It depends on both.

Best wishes


Mark.

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Re: AstraZeneca PLC (AZN)

#570338

Postby yorkshirelad1 » February 22nd, 2023, 5:19 pm

I've just been looking at the AZN 2022 AR recently published (https://www.astrazeneca.com/investor-relations/annual-reports.html), esp in relation to the dividends, and it's the most confusing piece of work, and you have to look very carefully

Right up at the front on page 4 and as part of the Chairman's statement, it says dividend 2.87 to 2.9
Image


On page 181 you have
Image
On page 211 you have
Image
and these latter two which say 2.80 to 2.90

How is it possible to put such contradictory information in an annual report without clarification. And what should one use as a yardstick when comparing annual dividends. I know it's probably mostly down to the calendar, but really? My head hurts....

I suppose either way, it's gone up in cents (and gone up in GBP 210.1p->239.2p (+13.9%) courtesy of the exchange rate)

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Re: AstraZeneca PLC (AZN)

#570348

Postby yorkshirelad1 » February 22nd, 2023, 5:49 pm

yorkshirelad1 wrote:I've just been looking at the AZN 2022 AR recently published (https://www.astrazeneca.com/investor-relations/annual-reports.html), esp in relation to the dividends, and it's the most confusing piece of work, and you have to look very carefully


Even the IC has got a bit confused with the dividend per share figures (either in its currency denomination or being consistent....)
Image

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Re: AstraZeneca PLC (AZN)

#570417

Postby idpickering » February 23rd, 2023, 7:05 am

AstraZeneca enters license agreement with KYM Biosciences for CMG901, a Claudin-18.2 antibody drug conjugate.

AstraZeneca and KYM Biosciences Inc.i have entered into a global exclusive licence agreement for CMG901, a potential first-in-class antibody drug conjugate (ADC) targeting Claudin 18.2, a promising therapeutic target in gastric cancer. Under the licence agreement, AstraZeneca will be responsible for the research, development, manufacture and commercialisation of CMG901 globally.


https://www.investegate.co.uk/astrazene ... 00087762Q/

Ian.

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Re: AstraZeneca PLC (AZN)

#570434

Postby ADrunkenMarcus » February 23rd, 2023, 7:55 am

yorkshirelad1 wrote:I've just been looking at the AZN 2022 AR recently published (https://www.astrazeneca.com/investor-relations/annual-reports.html), esp in relation to the dividends, and it's the most confusing piece of work, and you have to look very carefully

Right up at the front on page 4 and as part of the Chairman's statement, it says dividend 2.87 to 2.9
Image


On page 181 you have
Image
On page 211 you have
Image
and these latter two which say 2.80 to 2.90

How is it possible to put such contradictory information in an annual report without clarification. And what should one use as a yardstick when comparing annual dividends. I know it's probably mostly down to the calendar, but really? My head hurts....

I suppose either way, it's gone up in cents (and gone up in GBP 210.1p->239.2p (+13.9%) courtesy of the exchange rate)


It is confusing!

AZN can refer to either the calendar year paid or the financial year they relate to.

I’ve recorded the dividends I received by the tax year they were paid and track them that way.

Best wishes


Mark

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Re: AstraZeneca PLC (AZN)

#570819

Postby idpickering » February 24th, 2023, 2:35 pm

Acquisition of CinCor Pharma complete.

AstraZeneca announced today the successful completion of the acquisition of CinCor Pharma, Inc. (CinCor), a US-based clinical-stage biopharmaceutical company, focused on developing novel treatments for resistant and uncontrolled hypertension as well as chronic kidney disease.

The acquisition bolsters AstraZeneca's cardiorenal pipeline by adding baxdrostat (CIN-107), an aldosterone synthase inhibitor (ASI) for blood pressure lowering in treatment-resistant hypertension, to its cardiorenal portfolio.

Baxdrostat represents a potentially leading next-generation ASI as it is highly selective for aldosterone synthase and spares the cortisol pathway in humans1. The opportunity also brings the potential for combination with Farxiga and complements AstraZeneca's strategy to provide added benefit across cardiorenal diseases, where there is a high unmet medical need.

The acquisition was completed through a tender offer to purchase all outstanding shares of CinCor for approximately $1.3bn upfront. As part of the transaction, AstraZeneca acquired the cash and marketable securities on CinCor's balance sheet, which totalled approximately $500 million as of the closing, excluding transaction-related expenses. Under the terms of the agreement, CinCor shareholders also received a non-tradable contingent value right, payable upon a specified regulatory submission of a baxdrostat product. Combined, the upfront and contingent value payments represent, if achieved, a transaction value of approximately $1.8bn. As of the expiration of the tender offer, 39,580,275 shares of CinCor were validly tendered and not validly withdrawn from the tender offer, representing approximately 86.3% of the outstanding shares of common stock of CinCor, and such shares have been accepted for payment in accordance with the terms of the tender offer. CinCor's shares will be delisted from the Nasdaq Stock Market, and CinCor will terminate its registration under the U.S. Securities Exchange Act of 1934 as soon as practicable following completion of the acquisition.


https://www.investegate.co.uk/astrazene ... 05010330R/

Ian.

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Re: AstraZeneca PLC (AZN)

#573180

Postby idpickering » March 6th, 2023, 7:16 am

Enhertu DESTINY-PanTumor02 shows positive results.

Positive high-level results from an analysis of the ongoing DESTINY-PanTumor02 Phase II trial showed AstraZeneca and Daiichi Sankyo's Enhertu (trastuzumab deruxtecan) met the prespecified target for objective response rate (ORR) and demonstrated durable response across multiple HER2-expressing advanced solid tumours in heavily pretreated patients.


https://www.investegate.co.uk/astrazene ... 00049262R/

Ian (I hold).


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